Epidemiology

Etiology

Pathophysiology

Clinical features

Diagnostics

• Schizoaffective: Psychosis both with and without mood episodes.
• Depressive/Bipolar Disorder with Psychotic Features: Psychosis only during depressive or manic episodes.
• Schizophrenia: Psychosis dominant; mood issues are minor, transient, or absent.

1. An uninterrupted duration of illness during which there is a major mood episode (manic or depressive) in addition to criterion A for schizophrenia; the major depressive episode must include depressed mood.
2. Hallucinations and delusions for two or more weeks in the absence of a major mood episode (manic or depressive) during the entire lifetime duration of the illness.
3. Symptoms that meet the criteria for a major mood episode are present for most of the total duration of both the active and residual portions of the illness.
4. The disturbance is not the result of the effects of a substance (e.g., a drug of misuse or a medication) or another underlying medical condition.

• ≥ 2 weeks of psychosis without prominent manic/depressive symptoms during the illness episode, to differentiate from a mood disorder with psychotic features (Like MDD)
  • MDD doesn't have psychotic symptoms alone without mood symptoms
• A single illness episode where both of the following occur concurrently:
  • Psychotic symptoms that meet the criteria for schizophrenia
  • Features of a major mood episode (major depressive episode OR manic episode OR mixed episode)
• Psychotic symptoms occur at least once in the absence of mood disorder symptoms.

Treatment